Cholesterol myristate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

肉豆蔻酸胆固醇是传统中药中存在的天然类固醇。胆固醇肉豆蔻酸酯与多种离子通道结合，例如烟碱乙酰胆碱受体、GABAA 受体和内向整流钾离子通道。

Cholesterol myristate is a natural steroid present in traditional Chinese medicine. Cholesterol myristate binds to several ion channels such as the nicotinic acetylcholine receptor GABAA receptor and the inward-rectifier potassium ion channel.

Mesenchymal stem cells (MSCs) transfected by the Id1 promoter reporter construct, cholesterol myristate increases the activity of Id1 promoter. Cholesterol myristate inhibits the apoptosis of MSCs induced by serum-free. Cholesterol myristate increases the expression of Id1 and its target gene bcl-x/l in MSCs treated with serum-free. Moreover, noggin, a BMP antagonist, reduces the anti-apoptotic effects of cholesterol myristate. Cholesterol myristate inhibits the apoptosis of PC12 cells induced in serum-free condition. Cholesterol myristate significantly increases the expression of BMP4, BMPRIA, p-Smad1/5/8, Id1 and its antiapoptotic target gene Bcl-xL in PC12 cells treated in serum-free condition.

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Cholesteryl myristate | Cholesteryl tetradecanoate

Others

Other Targets

nicotinic acetylcholine receptor|GABAA receptor|inward-rectifier potassium ion channel

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1989-52-2

597.01

C41H72O2

>98% (HPLC)

Ethanol:2 mg/mL (3.35 mM)

CCCCCCCCCCCCCC(=O)O[C@H]1CC[C@@]2([C@H]3CC[C@]4([C@H]([C@@H]3CC=C2C1)CC[C@@H]4[C@H](C)CCCC(C)C)C)C

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(-20℃)

With Ice Pack

≥ 2 years